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Weight Loss May Change Brain SAN DIEGO MRI scans done after bariatric surgery reveal different patterns of brain activation in response to food cues according to a study reported here. Brain scans of obese patients who had lost 10 of their body weight revealed that less leptin leads to increased activity in regions of the brain that control our desire to eat. Here's what losing weight does to your body and brain. Several studies have shown that people who underwent weightloss surgery saw an improvement in memory, concentration, and problemsolving. Weight loss in the healthy obese, however, is associated with increased mortality. from a review of papers of the last 10 years, a timely reminder that health not weight loss is the important thing. World Health Organization (WHO) Updates Official Classification of Tumors of the Central Nervous System. 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